聚(乙二醇)

Semi-interpenetrating polymer network hydrogels between polydimethylsiloxane/polyethylene glycol and chitosan

ty10086 提交于 周四, 08/26/2021 - 13:45
Abstract(#br)Synthesis and properties of semi-interpenetrating polymer networks (semi-IPNs) based on polydimethylsiloxane (PDMS)/poly(ethylene glycol) (PEG)-modified chitosan were studied. 1–20\u003cce:hsp sp=\"0.25\"/\u003ewt% of PDMS or PEG was interpenetrated into chitosan hydrogels having 10\u003cce:hsp sp=\"0.25\"/\u003ewt% of hexamethylene-1,6-di-(aminocarboxysulfonate) (HDA) as a water-soluble crosslinker.

A versatile method for functionalization and grafting of 2-hydroxyethyl cellulose (HEC) via Click chemistry

ty10086 提交于 周四, 08/26/2021 - 13:40
Abstract(#br)This article describes a versatile method for the modification of 2-hydroxyethyl cellulose (HEC) involving azide-alkyne cycloaddition reaction to impart neutral (ester) and ionic (carboxylic acid and 1 ry amine) functionalities. The synthetic approach involved, first the introduction of the azide functionality to HEC and then followed by its cycloaddition reaction with several alkyne terminated compounds: namely ethyl propiolate, 5-hexynoic acid and propargyl amine.

癌症理论磁响应器件的设计与工程:从纳米到宏观

ty10086 提交于 周三, 08/25/2021 - 16:24
设计、研究和开发新型和改进的智能多功能器件是未来十年先进功能材料议程的主要议题之一。可以被外界刺激触发的智能材料被FDA、EMA等监管机构看到,具有很高的创新治疗和改进药物传递系统的潜力。将磁性纳米结构引入到复杂体系中,可以产生多功能的器件,并且可以通过外加磁场进行时空调控。这些磁响应器件可以用于从诊断到治疗肿瘤等多种生物医学应用,并正在积极开发和测试用于癌症治疗。在此,我们从最简单的结构——单一纳米粒子出发,综述了肿瘤磁响应器件的发展。我们在对此类系统的设计和制作给出一些理论概念的同时,对其在临床实践中的应用进行了批判性的综述。自然而然,该综述发展到更复杂的结构,从一维磁响应系统发展到三维磁响应系统,显示出更高的复杂性和多功能性,因此对临床实践的兴趣更高。审查的结尾是癌症理论磁响应器件的设计和工程面临的主要挑战以及这一生物医学领域的未来趋势。

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