微流体

Abstract(#br)Electrochemical detection of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) as labeling carriers in an assay for apolipoprotein E (ApoE) detection has been evaluated. The immunocomplex was performed by using tosylactivated magnetic beads as preconcentration platform into a flexible hybrid polydimethylsiloxane (PDMS)-polycarbonate (PC) microfluidic chip with integrated screen printed electrodes (SPE). All the immunoassay was performed in chip and in flow mode. The sensitive electrochemical detection was obtained by square wave anodic stripping voltammetry.

Abstract(#br)Open and closed electrowetting-on-dielectric (EWOD) systems based on a spin coated polydimethylsiloxane (PDMS) layer are presented. The PDMS layer acts as both insulation and hydrophobic material. Characterization, through sessile drop experiments, shows the hydrophobic behaviors of the PDMS and saturation of the contact angle at negative bias voltage applied to the droplet.

Abstract(#br)Culture of cells using various microfluidic devices is becoming more common within experimental cell biology. At the same time, a technological radiation of microfluidic cell culture device designs is currently in progress. Ultimately, the utility of microfluidic cell culture will be determined by its capacity to permit new insights into cellular function. Especially insights that would otherwise be difficult or impossible to obtain with macroscopic cell culture in traditional polystyrene dishes, flasks or well-plates.

Abstract(#br)A novel optofluidic surface-enhanced Raman scattering (SERS) chip was specially designed and fabricated using polydimethylsiloxane (PDMS) and embedded with normal silica multi-mode optical fibers. Unlike in a conventional Raman detection configuration where an angle of 90° is commonly adopted, here the orientations of the excitation fiber and the collection fiber was set at such an obtuse angle so that the light beam from the excitation fiber can illuminate the endface, but is not within the acceptance angle of the collection fiber.

Abstract(#br)In this report, a split ring resonator (SRR), the most important building block of metamaterial, is fabricated and integrated with a microfluidic chamber for biosensing. The SRR is produced on a microwave printed circuit board while the microfluidic chamber is fabricated by casting of polydimethylsiloxane (PDMS). SRR was immobilized with Anti- Immunoglobulin G (IgG) for IgG detection by a standard covalent immobilization using Cystamine.

Abstract(#br)The connection of tubes to a polydimethylsiloxane (PDMS) device can usually not be realised easily. Tube connectors embedded in the PDMS structure have a large foot print. Thick layers of PDMS in which the tubes or needles can hold hinders the visualisation of sample within the device. In this contribution we present microfluidic connectors for PDMS chips realized by easy-to-use elastomeric impression material polyvinylsiloxane (PVS).

Abstract(#br)This study presents a convenient avenue to fabricate polydimethylsiloxane (PDMS) with controllable surface morphologies and wetting characteristics via standard molding technique. The templates with engineered surface roughness were simply prepared by combinations of microfluidics and photo-polymerization of N -Isopropylacrylamide (NIPAM). The surface morphology of mold could be adjusted via ultraviolet-curing duration or the grafting density, which means that the surface of PDMS sample replicated from the mold could also be easily controlled based on the proposed method.

Abstract(#br)Bio-functionalized microfluidic systems were developed based on a silk protein hydrogel elastomeric materials. A facile multilayer fabrication method using gelatin sacrificial molding and layer-by-layer assembly was implemented to construct interconnected, three dimensional (3D) microchannel networks in silk hydrogels at 100 μm minimum feature resolution. Mechanically activated valves were implemented to demonstrate pneumatic control of microflow.

Abstract(#br)A process to fabricate superhydrophobic surfaces on metals and polymers is presented. Using high speed femtosecond laser pulses, surface structures have been created on metal surfaces and transferred onto Polydimethylsiloxane (PDMS) to achieve superhydrophobic surfaces. Various surface micro and nano structures are presented and their wetting properties are discussed. Water contact angles of over 150° with a roll off angle of less than 5° were achieved on the textured copper and PDMS surfaces.

Abstract(#br)Microfluidics is an emerging technology for synthesis of drug-loaded micro- and nano capsules for targeted delivery and controlled release, which has extensive applications in tumor therapy and pharmacological study in healthcare. A number of polydimethylsiloxane (PDMS) microfluidic devices have been developed and widely used, while PDMS based microstructure device does not support long-term stability and repeated use, moreover it requires special facilities for fabrication and plasma bonding.