红细胞

Abstract(#br)Polydimethylsiloxane (PDMS) has a wide variety of commercial and industrial applications due to its mechanical and rheological properties in a range similar to the living tissues. In this study, we demonstrate that PDMS can be used to produce deformable microparticles to be integrated in the development of particulate blood analogue fluids. The difficulties associated with the use of in vitro blood make it necessary to perform in vitro experiments of blood flow with blood analogue fluids.

Separation technique of the circulating tumor cell (CTC), which would be a sample for diagnostics of cancer, is important. In the present study, a micro flow device, which has gaps between micro-cylinders, has been fabricated by photolithography technique to distinguish between cancer cells and red blood cells. Two kinds of cells were used in the test: Hepa1-6 and swine red blood cell. The mean diameters of two kinds of cells measured by ImageJ were 21 μm and 6 μm. Variation was made on the dimension of the gap: 10, 15, 20 and 25 μm.