生物相容性

Abstract(#br)The monocyte-derived macrophage (MDM), present at biomaterial implantations, can increase, decrease or redirect the inflammatory and subsequent wound healing process associated with the presence of a biomaterial. Understanding MDM responses to biomaterials is important for improved prediction and design of biomaterials for tissue engineering. This study analyzed the direct differentiation of monocytes on intact, native collagen. Human monocytes were differentiated on decellularized bovine pericardium (DBP), polydimethylsiloxane (PDMS) or polystyrene (TCPS) for 14 d.

Abstract(#br)The connection of tubes to a polydimethylsiloxane (PDMS) device can usually not be realised easily. Tube connectors embedded in the PDMS structure have a large foot print. Thick layers of PDMS in which the tubes or needles can hold hinders the visualisation of sample within the device. In this contribution we present microfluidic connectors for PDMS chips realized by easy-to-use elastomeric impression material polyvinylsiloxane (PVS).

Abstract(#br)BC (bacterial cellulose) exhibits quite distinctive properties than plant cellulose. The outstanding properties make BC a promising material for preparation of artificial blood vessel. By taking advantage of the high oxygen permeability of PDMS (polydimethylsiloxane) as a tubular template material, a series of BC tubes with a length of 100\u003cce:hsp sp=\"0.25\"/\u003emm, a thickness of 1\u003cce:hsp sp=\"0.25\"/\u003emm and an outer diameter of 4 or 6\u003cce:hsp sp=\"0.25\"/\u003emm were biosynthesized with the help of Gluconacetobacter xylinum .

Abstract(#br)An active navigation of self-propelled miniaturized robot along the intestinal tract without injuring the soft tissue remains a challenge as yet. Particularly in this case an effective control of the interfacial friction and adhesion between the material used and the soft tissue is crucial. In the present study, we investigated the frictional and adhesive properties between polydimethylsiloxane (PDMS, microscopically patterned with micro-pillar arrays and non-patterned with a flat surface) and rabbit small intestinal tract using a universal material tester.

Abstract(#br)PDMS (Polydimethylsiloxane) thin films are widely used in stretchable electronics. However, it still remains challenging to fabricate PDMS thin films in an easy and convenient manner. To address this issue, here we novelly present an approach to ease the fabrication of PDMS membranes using lift-off method. For application as substrates in flexible biosensors, a gold thin film has been deposited on the PDMS thin film. The reliability of electric conductivity has been investigated. Moreover, biocompatibility of the PDMS thin film has been tested by culturing HeLa live cells it.

Abstract(#br)Since the local, on demand, cancer therapy is a challenging clinical issue today, this paper presents the design, fabrication and characterization of a remotely controlled single reservoir drug delivery chip using Ionic Polymer Metal Composite (IPMC) actuator. Here, Drug release was externally programmed and controlled wirelessly on demand by a communication circuit. The transmitter and receiver circuits were designed to control the release/sealed status remotely even from 7 cm distance while the transmitter and receiver were coupled magnetically.

Abstract(#br)The purpose of this paper was to develop the hydrophobic nanocomposite coatings of polydimethylsiloxane (PDMS)-SiO 2 -CuO to improve biocompatibility, corrosion resistance and antibacterial property of 316 L stainless. In this research, after synthesize of CuO and SiO 2 nanopowders using wet-chemical approaches, PDMS-SiO 2 -CuO coatings consisting of various amounts of CuO nanoparticles were developed using dip-coating process.

摘要\n功能梯度材料( FGMs )具有不同的空间、化学和机械梯度(连续或逐步)，具有模拟跨越生物组织发现的异质特性的潜力。它们可以防止应激集中，保持健康的细胞功能。这里，我们首次展示了聚二甲基硅氧烷和聚醚醚酮( PDMS- PEEK )复合材料的制备。这些材料成功地作为一种散体材料和功能梯度(逐步)制造，无需使用危险溶剂或需要添加剂。在没有形成硬的、边界界面的情况下，实现了层间(对于FGMs )的化学不可逆粘合。PDMS- PEEK FGMs的力学性能被证明可以在整个构建体积中进一步裁剪，模拟从软到硬组织的转变。在PDMS基体中引入20 wt % PEEK颗粒后，拉伸和压缩载荷下的弹性模量显著提高。生物和热筛选表明，这些复合材料对人成纤维细胞细胞株无不良影响，能在体温下保留物理状态和质量，可使复合材料适用于颌面部假体、人工血管和关节软骨置换等一系列生物医学应用。

In vitro Cytotoxicity Evaluation of Polydimethylsiloxane as a Biosensor Coating Materialcytotoxicity;biocompatibility;polydimethylsiloxane;MTT;cell morphology;PDMS was selected for a coating material of implantable biosensors and the cytotoxicity of extracts released from a polymer was evaluated using ISO 10993-5, Biological evaluation of medical devices-Part 5: Tests for in vitro cytotoxicity. Organo-tin was used as a positive control and a medium without serum was used as a negative control.

Parylene作为一种优良的阻隔材料，在许多领域得到了广泛的应用。但是，常规的聚对苯不能忍受医疗灭菌程序，包括高温灭菌和紫外线消毒，限制了其医疗应用。一种新型的Parylene成员Parylene F克服了上述缺点，在医学应用中显示出潜力。本工作通过化学气相沉积( CVD )方法在两种聚二甲基硅氧烷( PDMS )衬底上沉积了Parylene F (型AF4 )，制备的Parylene F的厚度分别为1μm ( PDMS-PF-1 )和5μm ( PDMS-PF-5 )。我们首次考察了Parylene F的防污性能和生物相容性，发现了一个有趣的现象，即parylene F表现出了双重作用的防污活性——抗黏附和抗菌。对于革兰氏阴性菌大肠杆菌，PDMS-PF-1 ( 0.69±0.25 % )和PDMS-PF-5 ( 0.5±0.1 % )的污垢面积占总面积的比例明显低于原始PDMS ( 6±0.77 % )。PDMS-PF-1 ( 45.49 ± 9.58 % )和PDMS - PF - 5 ( 45.3 ± 8.8 % )的抗菌率(死/总菌)均高于原始PDMS ( 28.12 ± 3.26 % )。对革兰氏阳性菌枯草芽孢杆菌的试验也观察到类似的结果。抗黏附和抗菌特性的协同作用赋予了表面优异的防污性能。