心臓拍動を模倣する流体キャパシタを集積した肝臓オルガノイド作製用マイクロ流体デバイス
Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, conventional methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle these issues, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic-based cell culture platform integrating a fluidic capacitor to produce pressure stimuli with hydrostatic pressure.