Microfluidic chip-based nanoelectrode array as miniaturized biochemical sensing platform for prostate-specific antigen detection
Abstract(#br)A microfluidic biosensor chip with an embedded three-electrode configuration is developed for the study of the voltammetric response of a nanoelectrode array with controlled inter-electrode distance in a nanoliter-scale sample volume. The on-chip three-electrode cell consists of a 5\u003cce:hsp sp=\"0.25\"/\u003e×\u003cce:hsp sp=\"0.25\"/\u003e5 array of Au working nanoelectrodes with radii between 60 and 120\u003cce:hsp sp=\"0.25\"/\u003enm, a Cl 2 -plasma-treated Ag/AgCl reference electrode, and a Au counter electrode.