Detection of Exosomes by ZnO Nanowires Coated Three-Dimensional Scaffold Chip Device
Abstract(#br)Exosomes as cell-derived vesicles have the potential to be novel biomarkers for noninvasive diagnosis of cancers. However, cost-effective detection of exosomes in routine clinical settings is still challenging. Herein, we present a ZnO nanowires coated three-dimensional (3D) scaffold chip device for effective immunocapture and classically visible and colorimetric detection of exosomes. The chip device is composed of 3D Polydimethylsiloxane (PDMS) scaffold skeleton covered by free-standing ZnO nanowire array.