快速成型

Abstract(#br)Polydimethylsiloxane is a translucent silicone material present in most lab-on-a-chip devices. In membrane technology, polydimethylsiloxane provides a separation barrier for various applications such as oxygenation, vapor recovery and nanofiltration. The easy-to-use combination of silicon and crosslinker and its properties make it widely applicable for two-dimensional device geometries. Here we develop a new sacrificial lithography technique to produce three-dimensional membrane geometries using rapid prototyping.

CO\u003csub\u003e2\u003c/sub\u003e laser manufacturing has served as an enabling and reliable tool for rapid and cost-effective microfabrication over the past few decades. While a wide range of industrial and biological applications have been studied, the choice of materials fabricated across various laser parameters and systems is often confounded by their complex combinations.

过去几十年来，CO2激光制造一直是快速和具有成本效益的微细加工的有利和可靠工具。虽然人们已经研究了广泛的工业和生物应用，但是通过各种激光参数和系统制备的材料的选择往往被它们的复杂组合所混淆。本发明提供了一个使用敲击CO2激光打孔的统一程序，包括一系列激光参数、基底材料和各种产生的微结构，使其能够在多种下游组织/细胞基础上应用。重点阐述了激光对不同生物相容性材料的钻削效果和概念证明。首先，制备聚二甲基硅氧烷( PDMS )微针( MN )阵列模具，生成可溶解的聚乙烯吡咯烷酮/聚乙烯醇( PVP / PVA ) MNs用于经皮给药。第二，优化聚苯乙烯( PS )微孔阵列，形成尺寸可控的多细胞肿瘤球体( MCTSs )；第三，打孔盖玻璃，形成可用于捕获/定位细胞/球体的微孔径；第四，PS中通孔的创建被证实是一种可以在悬滴阵列中创建便于介质交换的通道的方法，是MCTSs生长和药物筛选的有利工具。