Application of polypropylene tubes as single-use and low-cost sorptive extraction materials for the determination of benzodiazepines and zolpidem in water samples

由 ty10086 提交于 周四, 08/26/2021 - 13:31
文章英文标题
Application of polypropylene tubes as single-use and low-cost sorptive extraction materials for the determination of benzodiazepines and zolpidem in water samples
正文
Abstract(#br)This work presents a method for the simultaneous determination in water of 17 benzodiazepines (BZPs) and a related pharmaceutical (zolpidem) by extraction with low-cost polymeric sorbents followed by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Different polymers were considered: polydimethylsiloxane (PDMS), polypropylene (PP), and polyethersulfone (PES), providing the second one (PP) higher responses. Hence, different operational parameters were considered and optimized using PP as polymeric material for the extraction: ionic strength (as NaCl addition), sample pH, sample volume, extraction time, amount of extractant phase, desorption solvent and desorption time. Under the optimized conditions, 70\u003cce:hsp sp=\"0.25\"/\u003emL of sample (pH\u003cce:hsp sp=\"0.25\"/\u003e9) with 30% (w/v) of NaCl was extracted with four PP tubes (10\u003cce:hsp sp=\"0.25\"/\u003emm, ≈\u003cce:hsp sp=\"0.10\"/\u003e1\u003cce:hsp sp=\"0.25\"/\u003emg each) during 14\u003cce:hsp sp=\"0.25\"/\u003eh at room temperature, the analytes eluted with 1\u003cce:hsp sp=\"0.25\"/\u003emL of acetone and the eluate concentrated to dryness, reconstituted in methanol and analyzed by LC–MS/MS. Under these conditions, extraction efficiencies ranged between 41 and 86%, leading to enrichment factors from 574 to 1204. Satisfactory trueness, expressed as relative recoveries, was obtained in the 87–117% range. LOQs ranged from 0.4 to 31\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 and from 2 to 94\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 for river and influent wastewater, respectively. None of the analytes were detected in river water while 6 of them were detected in wastewater samples in concentrations between 4 and 152\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 , being lorazepam and oxazepam the analytes detected at the highest concentration level. Thus, PP may become a good alternative to PDMS or PES for the extraction of basic analytes.
文章内容（英文）
Abstract(#br)This work presents a method for the simultaneous determination in water of 17 benzodiazepines (BZPs) and a related pharmaceutical (zolpidem) by extraction with low-cost polymeric sorbents followed by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Different polymers were considered: polydimethylsiloxane (PDMS), polypropylene (PP), and polyethersulfone (PES), providing the second one (PP) higher responses. Hence, different operational parameters were considered and optimized using PP as polymeric material for the extraction: ionic strength (as NaCl addition), sample pH, sample volume, extraction time, amount of extractant phase, desorption solvent and desorption time. Under the optimized conditions, 70\u003cce:hsp sp=\"0.25\"/\u003emL of sample (pH\u003cce:hsp sp=\"0.25\"/\u003e9) with 30% (w/v) of NaCl was extracted with four PP tubes (10\u003cce:hsp sp=\"0.25\"/\u003emm, ≈\u003cce:hsp sp=\"0.10\"/\u003e1\u003cce:hsp sp=\"0.25\"/\u003emg each) during 14\u003cce:hsp sp=\"0.25\"/\u003eh at room temperature, the analytes eluted with 1\u003cce:hsp sp=\"0.25\"/\u003emL of acetone and the eluate concentrated to dryness, reconstituted in methanol and analyzed by LC–MS/MS. Under these conditions, extraction efficiencies ranged between 41 and 86%, leading to enrichment factors from 574 to 1204. Satisfactory trueness, expressed as relative recoveries, was obtained in the 87–117% range. LOQs ranged from 0.4 to 31\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 and from 2 to 94\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 for river and influent wastewater, respectively. None of the analytes were detected in river water while 6 of them were detected in wastewater samples in concentrations between 4 and 152\u003cce:hsp sp=\"0.25\"/\u003eng\u003cce:hsp sp=\"0.25\"/\u003eL −\u003cce:hsp sp=\"0.10\"/\u003e1 , being lorazepam and oxazepam the analytes detected at the highest concentration level. Thus, PP may become a good alternative to PDMS or PES for the extraction of basic analytes.
来源出处
Journal|[J]Microchemical JournalVolume 119, 2015. PP 58-65
DOI
https://doi.org/10.1016/j.microc.2014.10.011

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